Herophilus of Chalcedon and the Hippocratic tradition in early Alexandrian medicine.

Herophilus of Chalcedon (c. 330-250 BC) is famous as one of the leading figures in the development of medicine in Ptolemaic Alexandria around the first half of the third century BC. However, his medical science seems to have intrinsic continuity of thought with Hippocratic medicine. Herophilus followed the medical principle formulated in the Hippocratic treatise "On the Nature of Man," when he made his methodological pronouncement to the effect that primary parts of the human body should be perceptible by the senses. Herophilus rejected cardiocentrism, introduced by his teacher Praxagoras into the medical school of Cos, and returned to Hippocratic encephalocentrism, as represented by the author of the Hippocratic treatise "On the Sacred Disease." Herophilus differentiated between the faculties of the soul and the ones attributed to the nature. In his differentiation between these two faculties, Herophilus probably had in mind the Hippocratic conception of nature as specifically applied to the domain of the human body, as distinct from the soul. Herophilus' commitment to Hippocratic medicine is confirmed by his literary works on some of the Hippocratic texts. It is probable that Herophilus regarded himself as a more faithful successor than his teacher to the tradition of Hippocratic medicine. His anatomical research on the structure and function of the brain, motivated by his loyalty to the Hippocratic tradition, led him to innovative contributions to the development of medicine.