Laboratory of Cellular and Molecular Neurobiology, Graduate School of Frontier Biosciences, Osaka University, Yamadaoka, Suita, Osaka, Japan.
Eur J Neurosci. 2012 May;35(10):1595-604. doi: 10.1111/j.1460-9568.2012.08101.x.
An overwhelming number of observations demonstrate that neural activity and genetic programs interact to specify the composition and organization of neural circuits during all stages of development. Spontaneous neuronal activities have been documented in several developing neural regions in both invertebrates and vertebrates, and their roles are mostly conserved among species. Among these roles, Ca(2+) spikes and levels of electrical activity have been shown to regulate neurite growth, axon extension and axon branching. Here, we review selected findings concerning the role of spontaneous activity on circuit development.
大量的观察表明，神经活动和遗传程序在发育的所有阶段相互作用，以指定神经回路的组成和组织。在无脊椎动物和脊椎动物的几个发育中的神经区域都记录到了自发的神经元活动，并且它们在物种之间的作用大多是保守的。在这些作用中，钙（Ca(2+)） spikes 和电活动水平被证明可以调节神经突生长、轴突延伸和轴突分支。在这里，我们回顾了关于自发活动对回路发育作用的一些选定发现。
