Department of Stomatology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
J Oral Pathol Med. 2012 Nov;41(10):748-54. doi: 10.1111/j.1600-0714.2012.01166.x. Epub 2012 May 19.
The development of betel-quid (BQ) processing industry in Hunan has increased the usage of this substance and may produce significant health consequences. However, the update data for the prevalence of BQ chewing and its effect on oral submucous fibrosis (OSF) are limited.
A population-based survey was conducted to investigate the prevalence of BQ chewing and OSF in Hunan. A questionnaire interview and an oral examination were conducted. A multivariate logistic regression model was used to study the effect of socio-demographic characteristics on area-specific behaviors of BQ chewing.
A total of 2356 subjects participated in this survey, with a 78.5% of response rate. The lifetime prevalence of BQ chewing was 16.2% (2.9% for ex-chewers and 13.3% for current-chewers). The findings from multivariate logistic regression model showed that a higher prevalence of this habit was among individuals who were males, urban residents, 15-49 years old, educated for 9-12 years, smokers, and drinkers. Male chewers occupied a fairly higher percentage of the combined use of tobacco and/or alcohol (86.1-87.5%) than the non-chewers (50.6-56.7%). The overall prevalence of OSF was 1.0%. Compared with the subjects without OSF (1.7-23.2%), a significantly higher proportion of OSF patients were a current-chewer (62.3% in men and 100.0% in women).
BQ chewing is a vital risk factor for OSF in Hunan. A high prevalence of BQ chewing found among the younger cohort (15-49 years old) is an urgent warning for this oral premalignant disorder.
湖南地区槟榔加工业的发展增加了槟榔的使用量，可能会产生重大的健康后果。然而，目前关于咀嚼槟榔的流行情况及其对口腔黏膜下纤维性变（OSF）影响的更新数据有限。
本研究采用基于人群的调查方法，调查了湖南地区咀嚼槟榔和 OSF 的流行情况。通过问卷调查和口腔检查收集数据。采用多变量逻辑回归模型研究社会人口特征对特定地区咀嚼槟榔行为的影响。
共有 2356 名参与者参与了本调查，应答率为 78.5%。咀嚼槟榔的终生患病率为 16.2%（曾嚼者占 2.9%，现嚼者占 13.3%）。多变量逻辑回归模型的结果表明，男性、城镇居民、15-49 岁、受教育 9-12 年、吸烟者和饮酒者咀嚼槟榔的比例较高。男性嚼槟榔者同时使用烟草和/或酒精的比例（86.1%-87.5%）明显高于非嚼槟榔者（50.6%-56.7%）。OSF 的总患病率为 1.0%。与无 OSF 的患者相比（1.7%-23.2%），OSF 患者中嚼槟榔者的比例显著更高（男性为 62.3%，女性为 100.0%）。
咀嚼槟榔是湖南地区 OSF 的一个重要危险因素。在年龄较小的队列（15-49 岁）中发现咀嚼槟榔的高患病率，对口腔黏膜下纤维性变这种口腔癌前病变发出了紧急警告。
