School of Nursing and Midwifery, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Public Health. 2012 Jul;126(7):561-5. doi: 10.1016/j.puhe.2012.03.010. Epub 2012 May 16.
To compare blood pressure between 50-year-old adults who were born at term (37-42 weeks of gestation) with intra-uterine growth restriction (IUGR; birth weight <10th centile) and a control group of similar age born at term without IUGR (birth weight ≥10th centile).
Controlled comparative study.
Participants included 232 men and women who were born at the Royal Maternity Hospital, Belfast, a large regional maternity hospital in Northern Ireland, between 1954 and 1956. One hundred and eight subjects who were born with IUGR were compared with 124 controls with normal birth weight for gestation. The main outcome measures were systolic and diastolic blood pressure at approximately 50 years of age, measured according to European recommendations.
The IUGR group had higher systolic and diastolic blood pressure than the control group: 131.5 [95% confidence interval (CI) 127.9-135.1] vs 127.1 (95% CI 124.3-129.2) mmHg and 82.3 (95% CI 79.6-85.0) vs 79.0 (95% CI 77.0-81.0) mmHg, respectively. After adjustment for gender, the differences between the groups were statistically significant: systolic blood pressure 4.5 (95% CI 0.3-8.7) mmHg and diastolic blood pressure 3.4 (95% CI 0.2-6.5) mmHg (both P < 0.05). More participants in the IUGR group were receiving treatment for high blood pressure compared with the control group [16 (15%) vs 11 (9%)], although this was not statistically significant. The proportion of subjects with blood pressure >140/90 mmHg or currently receiving antihypertensive treatment was 45% (n = 49) for the IUGR group, and 31% (n = 38) for the control group (odds ratio 1.9, 95% CI 1.1-3.3). Adjustment for potential confounders made little difference.
IUGR is associated with higher blood pressure at 50 years of age. Individuals born with IUGR should have regular blood pressure screening and early treatment as required. Hypertension remains underdiagnosed and undertreated in adult life.
比较在宫内生长受限（IUGR；出生体重<第 10 百分位数）和足月出生且无 IUGR（出生体重≥第 10 百分位数）的对照组中，50 岁成年人的血压差异。
对照研究。
参与者包括 1954 年至 1956 年期间在北爱尔兰贝尔法斯特皇家妇产医院出生的 232 名男性和女性。将 108 名患有 IUGR 的受试者与 124 名出生体重正常的对照组进行比较。主要观察指标为按照欧洲建议测量的约 50 岁时的收缩压和舒张压。
IUGR 组的收缩压和舒张压均高于对照组：131.5[95%置信区间（CI）127.9-135.1] vs 127.1（95% CI 124.3-129.2）mmHg 和 82.3（95% CI 79.6-85.0）vs 79.0（95% CI 77.0-81.0）mmHg。在调整性别后，两组间的差异具有统计学意义：收缩压 4.5（95% CI 0.3-8.7）mmHg，舒张压 3.4（95% CI 0.2-6.5）mmHg（均 P<0.05）。与对照组相比，IUGR 组接受高血压治疗的患者更多[16（15%）vs 11（9%）]，尽管差异无统计学意义。IUGR 组血压>140/90mmHg 的患者比例或正在接受降压治疗的患者比例为 45%（n=49），对照组为 31%（n=38）（比值比 1.9，95% CI 1.1-3.3）。调整潜在混杂因素后差异无统计学意义。
IUGR 与 50 岁时的高血压相关。患有 IUGR 的个体应定期进行血压筛查，并根据需要进行早期治疗。成人高血压的诊断和治疗仍不足。
