Neuroscience Institute, The Queen's Medical Center, Honolulu, HI 96813, USA.
J Clin Anesth. 2012 Jun;24(4):318-23. doi: 10.1016/j.jclinane.2011.10.011.
The safety and efficacy of osmotic therapy with mannitol and 3% saline in the pediatric head-injured population has been widely reported; the use of 23.4% saline in children for the treatment of refractory intracranial hypertension has not. The clinical and physiologic responses of multiple 23.4% saline boluses in two children with severe traumatic brain injury (TBI) are presented. No complications were associated with the use of 23.4% saline in either patient.
甘露醇和 3%盐水的渗透性治疗在小儿颅脑损伤人群中的安全性和有效性已被广泛报道;然而,尚未有研究报道 23.4%盐水在儿童中的应用,以治疗难治性颅内高压。本文报告了两例严重创伤性脑损伤(TBI)患儿多次使用 23.4%盐水后的临床和生理反应。在这两例患者中,使用 23.4%盐水均未出现相关并发症。