Hayashi Y, Takahashi M, Yoshimura H
Division of Pathology, National Institute of Hygienic Sciences.
Gan To Kagaku Ryoho. 1990 Dec;17(12):2293-8.
Chemotherapeutic treatment for cancer has been successful in prolonging survival but it has also been demonstrated that survivors of cancer patients who had received chemotherapy with alkylating agents have an increased risk of second malignancies, mostly acute non-lymphatic leukemia. The purpose of this paper is to show practical problems pertaining to the development and clinical use of anticancer agents in terms of prevention of second cancers.
癌症的化疗治疗在延长生存期方面取得了成功，但也已证明，接受烷化剂化疗的癌症患者幸存者患第二种恶性肿瘤的风险增加，其中大多数为急性非淋巴细胞白血病。本文的目的是从预防第二种癌症的角度展示与抗癌药物研发和临床应用相关的实际问题。
