Kimura E, Kobayashi S, Terashima Y
Dept. of Obstetrics and Gynecology, Jikei University School of Medicine.
Gan To Kagaku Ryoho. 1990 Dec;17(12):2443-50.
PAP smears and biopsies are very effective in mass screening for uterine cancer. However, in this study, we tried to determine whether tumor markers could be useful for ovarian cancer screening. Eight tumor markers (CA125, TPA, CEA, ALP, amylase, LDH, CRP, IAP) were tested in serum samples from 3,540 women and the values were supplied to a CAMPAS (computer aided multivariate and pattern analysis system). Using this system, we managed to reduce the false positive rate to 0.68% but we couldn't prove the sensitivity of this system, because there were no ovarian cancer cases in this group. At this time, it is important to determine the high risk group of ovarian cancer for reducing the cost of mass screening. Finally, if tumor markers are to become more effective for ovarian cancer screening, it will be necessary to find ones that are more sensitive to ovarian cancer.
巴氏涂片和活检在子宫癌大规模筛查中非常有效。然而，在本研究中，我们试图确定肿瘤标志物是否可用于卵巢癌筛查。对3540名女性的血清样本检测了八种肿瘤标志物（CA125、组织多肽抗原、癌胚抗原、碱性磷酸酶、淀粉酶、乳酸脱氢酶、C反应蛋白、免疫抑制酸性蛋白），并将这些值输入到一个计算机辅助多变量和模式分析系统（CAMPAS）中。使用该系统，我们成功地将假阳性率降低到了0.68%，但由于该组中没有卵巢癌病例，我们无法证明该系统的敏感性。此时，确定卵巢癌的高危人群对于降低大规模筛查成本很重要。最后，如果肿瘤标志物要在卵巢癌筛查中变得更有效，就有必要找到对卵巢癌更敏感的标志物。
