Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology at University of North Carolina School of Medicine, Chapel Hill, NC 27599-7516, USA.
Am J Obstet Gynecol. 2012 Jul;207(1):62.e1-7. doi: 10.1016/j.ajog.2012.04.035. Epub 2012 May 2.
The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome.
In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity.
Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass.
Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.
本研究旨在评估孕前体重指数（BMI）与妊娠结局的关系，而不考虑 3 小时口服葡萄糖耐量试验（OGTT）的结果。
在这项对未经治疗的轻度妊娠期葡萄糖耐量异常队列的二次分析中，将 50g 葡萄糖负荷试验在 135-199mg/dL 之间且空腹血糖水平<95mg/dL 定义为轻度妊娠期葡萄糖耐量异常，我们对孕前 BMI、OGTT 结果与妊娠并发症和新生儿肥胖之间的关系进行建模。
在 1250 名参与者中，孕前 BMI 和 OGTT 第 3 小时的血糖均与妊娠期高血压的风险增加相关。产妇孕前 BMI 也与巨大儿呈正相关；母体 BMI 和空腹血糖均与出生体重 z 评分和新生儿脂肪量有关。
在未经治疗的轻度妊娠期葡萄糖耐量异常的女性中，孕前 BMI 与妊娠期高血压、出生体重和新生儿脂肪量增加有关，而与 OGTT 值无关。
