Liver Unit, Birmingham Children's Hospital, West Midlands, United Kingdom.
Clin Res Hepatol Gastroenterol. 2012 Jun;36(3):253-6. doi: 10.1016/j.clinre.2012.03.018. Epub 2012 May 18.
Neonatal jaundice lasting greater than 2 weeks should be investigated. Pale stools and dark or yellow urine are evidence of liver disease, which should be urgently investigated. The neonatal hepatitis syndrome has many causes, and a structured approach to investigation is mandatory. It should be possible to confirm or exclude biliary atresia within one week, so that definitive surgery is not delayed unnecessarily. Babies with the neonatal hepatitis syndrome should have vigorous fat-soluble vitamin supplementation, including parenteral vitamin K if coagulation is abnormal. The prognosis for infants with idiopathic neonatal hepatitis and multifactorial cholestasis is excellent.
新生儿黄疸持续时间超过 2 周应进行调查。浅色粪便和深色或黄色尿液提示肝脏疾病，应紧急调查。新生儿肝炎综合征有多种病因，因此必须采用结构化的方法进行调查。应能在一周内确诊或排除胆道闭锁，以免不必要地延误手术时机。患有新生儿肝炎综合征的婴儿应进行积极的脂溶性维生素补充，包括维生素 K 静脉注射，如果凝血异常的话。特发性新生儿肝炎和多因素胆汁淤积症患儿的预后极好。
