Rossi E G, Grinberg M, Mansur A J, Bellotti G, Pileggi F, Jatene A
Instituto do Coracão do Hospital das Clínicas da FMUSP.
Arq Bras Cardiol. 1990 Feb;54(2):101-4.
PURPOSE valve prolapse (MVP) cases, complicated with infective endocarditis (IE), seen at a cardiologic reference hospital.
The MVP cases were diagnosed within a series of 276 cases of IE without previous cardiac surgery with clinical-echocardiographic criteria. We emphasised in our study; a) incidence; b) age and sex distribution; c) risk factors for IE; d) clinical-bacteriological data; e) echocardiographic features; f) therapeutic aspects; f) evolution and complications.
a) We diagnosed 40 (14.4%) cases of MVP; b) mean age of 40.6 years, with 29 men (72.5%); c) dental procedures without prophylactic antibiotic-therapy in seven patients (17.5%), mitral regurgitation in 33 (82.5%), mitral valve redundancy in six (15%); d) fever was found in all patients (100%), cachexia was diagnosed in eight (20%), polyarthritis in six (15%) and congestive heart failure in six (15%). A systolic murmur of mitral regurgitation was found in all the patients and a nonejective click was encountered in four (10%), a Streptococcus was cultivated in 30 (75%), Staphylococcus in three (7.5%) Haemophilus sp in three (7.5%) Peptostreptococcus products in one (2.5%) and negative in three (7.5%) patients; e) echocardiographic signs of vegetation in 23 (57.5%), mitral regurgitation in 33 (82.5%), rupture of mitral chordae in 11 (27.5%) and mitral redundance in six (15.2%); f) 37 (92.5%) patients were medically treated and three (7.5%) required surgery; g) we registered in the hospital evolution: stroke in 10 (25%) and noncerebral mycotic aneurysm in 2 (5%) cases, two patients died (5%), one due to a hemorrhagic complication after surgery of bioprosthesis implantation and another of rupture of a cerebral mycotic aneurysm.
The MVP was frequent in the population of patients with IE with of patients with mitral regurgitation, and male with mean age greater than the other cases. We observed low incidence of surgical need (7.5%) and lethal outcome (5%) but frequent (25%) neurological complications.
目的 研究在一家心脏病专科医院就诊的合并感染性心内膜炎(IE)的二尖瓣脱垂(MVP)病例。
根据临床超声心动图标准,在276例未接受过心脏手术的IE病例系列中诊断出MVP病例。我们在研究中着重关注了:a)发病率;b)年龄和性别分布;c)IE的危险因素;d)临床细菌学数据;e)超声心动图特征;f)治疗方面;f)病情演变及并发症。
a)我们诊断出40例(14.4%)MVP病例;b)平均年龄40.6岁,男性29例(72.5%);c)7例患者(17.5%)在未进行预防性抗生素治疗的情况下接受了牙科手术,33例(82.5%)存在二尖瓣反流,6例(15%)存在二尖瓣瓣叶冗长;d)所有患者(100%)均有发热,8例(20%)被诊断为恶病质,6例(15%)有关节炎,6例(15%)有充血性心力衰竭。所有患者均有二尖瓣反流的收缩期杂音,4例(10%)可闻及非喷射性喀喇音,30例(75%)培养出链球菌,3例(7.5%)培养出葡萄球菌,3例(7.5%)培养出血流感杆菌,1例(2.5%)培养出消化链球菌属产物,3例(7.5%)患者培养结果为阴性;e)23例(57.5%)有赘生物的超声心动图表现,33例(82.5%)有二尖瓣反流,11例(27.5%)有二尖瓣腱索断裂,6例(15.2%)有二尖瓣瓣叶冗长;f)37例(92.5%)患者接受药物治疗,3例(7.5%)需要手术治疗;g)我们记录了住院期间的病情演变:10例(25%)发生中风,2例(