Ermolenko N A, Ermakov A Iu, Buchneva I A, Voronkova K V, Zakharova E I
Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(11 Pt 1):17-24.
We studied 1036 children with epileptic seizures, aged from 1 to 18 years, during 2004-2008. One hundred and six patients were diagnosed with idiopathic focal epilepsy (IFE). The following forms of IFE were singled out: benign seizures of infancy (familial and non-familial) - Watanabe--Vigevano syndrome - 5,7%, occipital epilepsy of childhood with early manifestation (Panayiotopoulos syndrome) -26,4%, occipital epilepsy of childhood with late manifestation (Gastaut syndrome) - 12,3%, benign epilepsy of childhood with central-temporal spikes (rolandic epilepsy) - 51%, benign focal epilepsy with affective symptoms - 4,7%. The efficacy of the first monotherapy was significantly worse in rolandic epilepsy compared to the other IFE forms. Prescription of valproate or the combination of valproate, ethosuximidum and levetiracetam, in case of resistant course, as a starting therapy was found optimal.
2004年至2008年期间,我们对1036名年龄在1至18岁之间患有癫痫发作的儿童进行了研究。106名患者被诊断为特发性局灶性癫痫(IFE)。IFE的以下几种类型被区分出来:婴儿良性癫痫(家族性和非家族性)——渡边-维杰瓦诺综合征——5.7%,儿童早期表现的枕叶癫痫(帕纳约托普洛斯综合征)——26.4%,儿童晚期表现的枕叶癫痫(加斯东综合征)——12.3%,儿童中央颞区棘波良性癫痫(罗兰多癫痫)——51%,伴有情感症状的良性局灶性癫痫——4.7%。与其他IFE类型相比,罗兰多癫痫的首次单一疗法疗效明显较差。在病程耐药的情况下,丙戊酸盐或丙戊酸盐、乙琥胺和左乙拉西坦的联合用药作为起始治疗被发现是最佳的。