Hospital de Pediatría "Prof. Dr. Juan P Garrahan", Buenos Aires, Argentina.
Hospital de Pediatría "Prof. Dr. Juan P Garrahan", Buenos Aires, Argentina.
Seizure. 2018 Apr;57:27-31. doi: 10.1016/j.seizure.2018.03.004. Epub 2018 Mar 9.
To present a retrospective study of 13 children with benign epilepsy with centrotemporal spikes (BECTS), also known as benign rolandic epilepsy (BRE), associated with generalized spikes and waves as the only EEG manifestation at onset.
Charts of children with typical clinical criteria of BRE electroclinically followed-up between February 2000 and February 2015 were reviewed.
Among 309 patients who met the electroclinical criteria of BRE, we identified 13 children who presented with the typical clinical manifestations but who, on the EEG, only had generalized paroxysms at onset that continued along the course of the syndrome. Generalized spike-and-wave discharges were observed in all patients when awake and during sleep (100%). During the evolution no particular electroclinical pattern was observed. The patients responded well to antiepileptic drugs, such as valproic acid and levetiracetam. Outcome was good in all patients.
We found evidence that patients with BRE may have generalized EEG discharges at onset as the sole manifestation lasting throughout the course of the syndrome. In some, focal paroxysms developed later. The course was benign. In our group of patients, clinical features and evolution were similar to those of typical cases of BRE. Response to valproic acid and levetiracetam was found to be particularly good.
回顾性分析 13 例以全面性棘慢波放电为唯一脑电图表现的儿童良性癫痫伴中央颞区棘波（BECTS），又称良性罗兰多癫痫（BRE）。
对 2000 年 2 月至 2015 年 2 月间符合典型临床 BRE 电临床标准并接受随访的患儿的病历进行了回顾。
在符合 BRE 电临床标准的 309 例患儿中，我们发现了 13 例患儿具有典型的临床表现，但脑电图仅在发作时出现全面性发作，且在整个疾病过程中持续存在。所有患者在清醒和睡眠时均观察到全面性棘慢波放电（100%）。在疾病的演变过程中，未观察到特殊的电临床模式。患者对抗癫痫药物（如丙戊酸和左乙拉西坦）反应良好。所有患者的结局均良好。
我们发现 BRE 患者可能有全面性脑电图放电作为唯一表现，持续贯穿整个疾病过程。在一些患者中，后来出现了局灶性发作。疾病过程是良性的。在我们的患者群体中，临床特征和演变与典型的 BRE 病例相似。发现丙戊酸和左乙拉西坦的反应特别好。
