Neurological Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
J Neuroimmunol. 2012 Aug 15;249(1-2):83-5. doi: 10.1016/j.jneuroim.2012.04.016. Epub 2012 May 19.
Mycophenolate mofetil (MMF) is used for immunosuppression in myasthenia gravis (MG). Although there are numerous data on associated infection and prophylaxis in transplant patients who are on MMF, data in MG remains lacking. We report two elderly seropositive MG patients who developed cytomegalovirus (CMV) enteritis and Epstein-Barr virus (EBV) encephalitis while on MMF for 5months and 1year, respectively. Chronic MMF therapy in MG patients may trigger life-threatening infections including CMV and EBV diseases, especially in the elderly. Similar to the practice in transplant patients, viral serology testing and appropriate prophylactic regimen with antiviral agents should be considered, particularly in older MG patients.
霉酚酸酯（MMF）用于重症肌无力（MG）的免疫抑制。尽管有大量关于接受 MMF 治疗的移植患者相关感染和预防的数据，但 MG 方面的数据仍然缺乏。我们报告了两名老年血清阳性 MG 患者，他们分别在接受 MMF 治疗 5 个月和 1 年后发生巨细胞病毒（CMV）肠炎和 EBV 脑炎。慢性 MMF 治疗可能会在 MG 患者中引发危及生命的感染，包括 CMV 和 EBV 疾病，尤其是在老年人中。类似于移植患者的做法，应考虑进行病毒血清学检测和适当的抗病毒药物预防方案，特别是在老年 MG 患者中。
