Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Netherlands Proteomics Centre, Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands.
Nucleus. 2012 Jul 1;3(4):322-9. doi: 10.4161/nucl.20439. Epub 2012 May 22.
The nuclear envelope protects and organizes the genome. The nuclear pore complexes embedded in the nuclear envelope allow selective transport of macromolecules between the cytosol and nucleoplasm, and as such help to control the flow of information from DNA to RNA to proteins. A growing list of integral membrane proteins of the nuclear envelope are described to function in the organization of the genome, as well as the assembly of the NPCs. Here, we discuss how the nuclear pore complex may sort these proteins to obtain a specific protein composition of the inner membrane.
核膜保护和组织基因组。嵌入核膜的核孔复合物允许细胞溶质和核质之间的大分子选择性运输，从而有助于控制从 DNA 到 RNA 再到蛋白质的信息流。越来越多的核膜的完整膜蛋白被描述为在基因组的组织以及 NPC 的组装中发挥作用。在这里，我们讨论核孔复合物如何对这些蛋白质进行分类，以获得内膜的特定蛋白质组成。
