Pinheiro L E, Mikich A B, Bechara G H, Almeida I L, Basrur P K
Department of Clinics and Surgery, FCAV, UNESP, Sao Paulo, Brazil.
Genome. 1990 Oct;33(5):690-5. doi: 10.1139/g90-104.
The chromosome makeup of a 3-year-old crossbred heifer was examined in an attempt to explore the cytogenetic causes of her infertility. The heifer proved to be a mosaic carrying predominantly XY cells and with approximately 30% of cells lacking a normal Y. The minor population included cells carrying a dicentric isochromosome Y and a small proportion of XO cells. Histological features of the gonads and reproductive system suggest that the presence of cells resulting from isochromosome formation and the consequent loss of the Y chromosome segment required for testicular induction may have been causally related to the embryonic state of the gonads and malformation of the duct system noted in this heifer.
