van Noord P A, Seidell J C, den Tonkelaar I, Baanders-van Halewijn E A, Ouwehand I J
Department of Epidemiology (Preventicon), University of Utrecht, The Netherlands.
Int J Epidemiol. 1990 Sep;19(3):564-70. doi: 10.1093/ije/19.3.564.
The prevalence of reported chronic diseases was studied in quintiles of waist/hip ratio and Quetelet index in 11,825 women aged 40-73 presenting for mammographic screening in the DOM-project. After adjustment for age and Quetelet index, increased waist/hip ratio was found to be associated with an increased prevalence of diabetes mellitus, hypertension, cholecystectomy and a lower prevalence of varicose veins. No associations were observed between waist/hip ratio and the prevalence of angina pectoris, gout and rheumatism. The odds ratios, adjusted for age and Quetelet index, of the highest versus the lowest quintile of waist/hip ratio were 3.4 (95% CI 1.4-8.3) for diabetes mellitus; 2.2 (95% CI 1.7-2.8) for hypertension; 2.0 (95% CI 1.2-3.4) for cholecystectomy, and 0.81 (95% CI 0.68-0.95) for varicose veins. After adjustment for waist/hip ratio and age, Quetelet index was found to be associated with an increased prevalence of hypertension, cholecystectomy and varicose veins. Quetelet index, however, was not found to be related to diabetes, gout or rheumatism. We conclude that in a representative sample of Dutch women older than 40 years, fat distribution in addition to overweight is related to important chronic diseases.
在DOM项目中，对11825名年龄在40 - 73岁、接受乳房X光筛查的女性，按照腰臀比和体重指数的五分位数，研究了报告的慢性病患病率。在对年龄和体重指数进行调整后，发现腰臀比增加与糖尿病、高血压、胆囊切除术患病率增加以及静脉曲张患病率降低有关。未观察到腰臀比与心绞痛、痛风和风湿病患病率之间存在关联。经年龄和体重指数调整后，腰臀比最高五分位数与最低五分位数相比的比值比，糖尿病为3.4（95%可信区间1.4 - 8.3）；高血压为2.2（95%可信区间1.7 - 2.8）；胆囊切除术为2.0（95%可信区间1.2 - 3.4）；静脉曲张为0.81（95%可信区间0.68 - 0.95）。在对腰臀比和年龄进行调整后，发现体重指数与高血压、胆囊切除术和静脉曲张患病率增加有关。然而，未发现体重指数与糖尿病、痛风或风湿病有关。我们得出结论，在40岁以上荷兰女性的代表性样本中，除超重外，脂肪分布与重要的慢性病有关。
