女性和男性的风险因素对重度抑郁症发病风险的差异影响。
Differential impact of risk factors for women and men on the risk of major depressive disorder.
机构信息
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
出版信息
Ann Epidemiol. 2012 Jun;22(6):388-96. doi: 10.1016/j.annepidem.2012.04.011.
PURPOSE
Our aim is to examine which risk factors have a greater impact in women than in men on the risk of major depressive disorder (MDD) and whether factors differ between a possible recurrent MDD and a first onset of MDD.
METHODS
Prospective cohort study of general practice attendees in seven countries, who were followed up at 6 and 12 months (predictD). Absolute risk differences (interaction contrast) across sex for onset of DSM-IV MDD after 6 or 12 months of follow-up were estimated for 35 risk factors from 7101 participants without MDD at baseline.
RESULTS
A total of 599 participants (80% female) had an onset of MDD at 6 or 12 months. Most risk factors had a greater impact in women than in men on the risk of MDD and were not restricted to a specific class of risk factors. After we stratified for a history of depressive symptoms, we found that the impact of risk factors across sex was generally stronger on possible recurrent MDD than on a first onset of MDD.
CONCLUSIONS
Our findings may partly account for the observed difference in incidence of MDD between men and women.
目的
我们旨在研究在女性中比男性对重度抑郁症（MDD）风险影响更大的风险因素有哪些，以及在可能的复发性 MDD 和首次发作 MDD 之间，这些因素是否存在差异。
方法
这是一项在七个国家的普通科医生就诊者中进行的前瞻性队列研究，参与者在 6 个月和 12 个月时进行随访（predictD）。对来自 7101 名基线时无 MDD 的参与者的 35 个风险因素，在 6 个月或 12 个月的随访后出现 DSM-IV MDD 的发病情况，估计了跨性别（交互对比）的绝对风险差异。
结果
共有 599 名参与者（80%为女性）在 6 或 12 个月时出现 MDD 发作。大多数风险因素对女性 MDD 风险的影响大于男性，而且不限于特定类别的风险因素。在我们对抑郁症状史进行分层后，我们发现跨性别的风险因素对可能的复发性 MDD 的影响通常比对首次发作 MDD 的影响更强。
结论
我们的研究结果可能部分解释了男性和女性之间 MDD 发病率的差异。
Zotero 插件