Department of Dermatology, Naga Municipal Hospital, Wakayama, Japan.
Exp Dermatol. 2012 Jul;21 Suppl 1:8-10. doi: 10.1111/j.1600-0625.2012.01495.x.
Skin stress response system (SSRS) involves corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC)-derived peptides, such as adrenocorticotropic hormone (ACTH), a-melanocyte-stimulating hormone (MSH) and b-endorphin that are locally generated in response to locally provided stressors or proinflammatory cytokines. This system would restrict tissue damage and restore local homoeostasis. Trichloroacetic acid (TCA) is one of the most widely used peeling agents and applied for cosmetic treatment of photodamaged skin. However, the biological mechanism responsible for TCA peeling has yet to be fully determined. While our investigation focused on the inflammation and wound healing pathways, in the recent study, we have examined involvement of the SSRS as the third pathway. Mostly depending on our findings that TCA peeling activates the SSRS by inducing the POMC expression of keratinocytes in the CRH-independent manner, together with the results reported by other researchers, we can say that the biological effect of POMC seems to be responsible for the TCA-induced epidermal SSRS activation.
皮肤应激反应系统（SSRS）涉及促肾上腺皮质激素释放激素（CRH）和源自前阿黑皮素原（POMC）的肽，如促肾上腺皮质激素（ACTH）、α-黑色素细胞刺激素（MSH）和β-内啡肽，这些肽在局部产生以应对局部提供的应激源或促炎细胞因子。该系统可以限制组织损伤并恢复局部的体内平衡。三氯乙酸（TCA）是最广泛使用的去皮剂之一，用于治疗光损伤皮肤的美容治疗。然而，负责 TCA 去皮的生物学机制尚未完全确定。虽然我们的研究重点是炎症和伤口愈合途径，但在最近的研究中，我们已经研究了 SSRS 的参与作为第三条途径。主要根据我们的发现，TCA 去皮通过以 CRH 独立的方式诱导角质形成细胞中的 POMC 表达来激活 SSRS，再加上其他研究人员的报告结果，我们可以说 POMC 的生物学效应似乎负责 TCA 诱导的表皮 SSRS 激活。
