Department of Pediatrics, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912, USA.
Ann Allergy Asthma Immunol. 2012 Jun;108(6):429-34. doi: 10.1016/j.anai.2012.04.008.
Prior studies have shown relationships between serum immunoglobulin E (IgE) and asthma.
To investigate relationships between total and allergen-specific IgE concentrations and lung function in young adults.
Measurements of total IgE, allergen-specific IgE to 6 common allergens, and spirometry (forced expiratory volume in one second [FEV(1)], forced vital capacity [FVC], FEV(1)/FVC, and percent change in FEV(1) after bronchodilation) were used to calculate correlations between the logarithmically transformed IgE values and measures of lung function among participants in a birth cohort not selected for risk of allergic disease stratified by current asthma, prior asthma, or no asthma.
The 428 participants were 51.6% female, 93% white, and 18.4 (standard deviation = 0.6) years old. Forty-eight (11.2%) had current asthma, 55 (12.9%) had a history of asthma, and 325 (75.9%) never had asthma. For males with current asthma, correlations between total IgE and FEV(1)% and FVC% were -0.51 (P = .06) and -0.70 (P = .005), respectively. For females with current asthma, the only significant correlation was between total IgE and the FEV(1)/FVC ratio (-0.55, P = .001). After excluding smokers and individuals without detectable allergen-specific IgE, the negative correlations for both males and females remained statistically significant. The correlations among males or females with prior asthma or no history of asthma were minimal and not statistically significant. The sum of the allergen-specific IgEs showed the same pattern of relationships to lung function as did total IgE.
Our results show significant negative correlations that vary by gender between both total and allergen-specific IgE and measurements of lung function in young adults with current asthma.
先前的研究表明血清免疫球蛋白 E（IgE）与哮喘之间存在关系。
调查成年早期总 IgE 和过敏原特异性 IgE 浓度与肺功能之间的关系。
使用总 IgE、6 种常见过敏原的过敏原特异性 IgE 以及肺活量测定（一秒用力呼气容积 [FEV1]、用力肺活量 [FVC]、FEV1/FVC 和支气管扩张后 FEV1 的百分比变化）来测量，以计算出生队列中参与者的 IgE 值的对数值与肺功能之间的相关性，该队列未选择过敏疾病的风险，按当前哮喘、既往哮喘或无哮喘分层。
428 名参与者中，女性占 51.6%，白人占 93%，年龄为 18.4（标准差=0.6）岁。48 人（11.2%）有当前哮喘，55 人（12.9%）有哮喘史，325 人（75.9%）从未有过哮喘。对于当前有哮喘的男性，总 IgE 与 FEV1%和 FVC%之间的相关性分别为-0.51（P=0.06）和-0.70（P=0.005）。对于当前有哮喘的女性，唯一有统计学意义的相关性是总 IgE 与 FEV1/FVC 比值（-0.55，P=0.001）之间的相关性。排除吸烟者和未检出过敏原特异性 IgE 的个体后，男性和女性的负相关仍然具有统计学意义。有既往哮喘或无哮喘史的男性或女性之间的相关性很小，且无统计学意义。过敏原特异性 IgE 的总和与肺功能之间存在与总 IgE 相同的关系模式。
我们的结果显示，在当前有哮喘的年轻成年人中，总 IgE 和过敏原特异性 IgE 与肺功能之间存在显著的负相关，且这种相关性因性别而异。
