Oh Sam S, Du Randal, Zeiger Andrew M, McGarry Meghan E, Hu Donglei, Thakur Neeta, Pino-Yanes Maria, Galanter Joshua M, Eng Celeste, Nishimura Katherine Keiko, Huntsman Scott, Farber Harold J, Meade Kelley, Avila Pedro, Serebrisky Denise, Bibbins-Domingo Kirsten, Lenoir Michael A, Ford Jean G, Brigino-Buenaventura Emerita, Rodriguez-Cintron William, Thyne Shannon M, Sen Saunak, Rodriguez-Santana Jose R, Williams Keoki, Kumar Rajesh, Burchard Esteban G
a Department of Medicine , University of California San Francisco , San Francisco , CA , USA.
b Department of Pharmacy , University of California San Francisco , San Francisco , CA , USA.
J Asthma. 2017 Oct;54(8):856-865. doi: 10.1080/02770903.2016.1266496. Epub 2016 Dec 8.
In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma.
As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8-21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations.
Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only.
Breastfeeding was associated with higher FEV% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.
在美国，与其他种族/族裔群体相比，波多黎各人和非裔美国人的母乳喂养率较低，且哮喘的临床结局更差。我们推测，母乳喂养史与哮喘的拉丁裔和非裔美国青少年的一秒用力呼气量（FEV）预测值增加及哮喘发作减少有关。
作为拉丁裔美国人基因-环境与混合研究（GALA II）以及非裔美国人哮喘、基因与环境研究（SAGE II）的一部分，我们对来自四个不同种族/族裔群体、年龄在8至21岁的哮喘儿童和青少年进行了仅病例分析：非裔美国人（n = 426）、墨西哥裔美国人（n = 424）、混血/其他拉丁裔（n = 255）和波多黎各人（n = 629）。我们使用多变量线性回归研究婴儿期任何母乳喂养与FEV预测值百分比之间的关联；采用泊松回归确定母乳喂养与哮喘发作之间的关联。
与墨西哥裔美国人（76.2%）和混血/其他拉丁裔（66.9%；p < 0.001）相比，非裔美国人（59.4%）和波多黎各人（54.9%）的母乳喂养率较低。在调整协变量后，仅在非裔美国人中，母乳喂养与FEV预测值百分比增加3.58个百分点（p = 0.01）及哮喘发作减少21%（p = 0.03）相关。
母乳喂养与哮喘患者较高的FEV预测值百分比及非裔美国青少年哮喘发作次数减少有关，这提醒人们要持续支持母乳喂养。
