Jonas A, Yahav J, Fradkin A, Kessler A, Rubinstein Z, Avigad I, Reichman B
Pediatric Gastroenterology Service, Chaim Sheba Medical Center, Tel Aviv, Israel.
J Pediatr Gastroenterol Nutr. 1990 Nov;11(4):513-7. doi: 10.1097/00005176-199011000-00012.
During the 3-year period, January 1986 through December 1988, 7 of 24 infants evaluated for cholestatic liver disease were found to have choledocholithiasis with or without associated gallbladder disease. Five were born prematurely with associated predisposing factors, especially systemic infection and total parenteral nutrition. The clinical course varied from spontaneous recovery in two patients to ongoing liver disease requiring surgical or endoscopic intervention in five infants. Asymptomatic patients with normal liver function and persistently dilated extrahepatic biliary trees posed the most difficult therapeutic problems. Endoscopic retrograde cholangiography appeared to be an effective and rewarding therapeutic approach.
在1986年1月至1988年12月的3年期间，对24例胆汁淤积性肝病患儿进行评估，发现其中7例患有胆总管结石，伴或不伴有胆囊疾病。5例为早产儿，伴有相关易感因素，尤其是全身感染和全胃肠外营养。临床病程各异，2例患者自发恢复，5例婴儿持续存在肝病，需要手术或内镜干预。肝功能正常但肝外胆管持续扩张的无症状患者带来了最棘手的治疗问题。内镜逆行胆管造影似乎是一种有效且值得采用的治疗方法。
