Fedotova Iu O
Patol Fiziol Eksp Ter. 2012 Jan-Mar(1):53-6.
The involvement of D2-receptors in learning/memory processes during ovary cycle was assessed in the adult female rats. Quinperole (0,1 mg/kg, i.p.), D2-receptor agonist and sulpiride (10,0 mg/kg, i.p.), D2-receptor antagonist were injected chronically to adult female rats. Learning of these animals was assessed in different models: passive avoidance performance and Morris water maze. Chronic quinperole administration to females resulted in the appearance of the passive avoidance performance in proestrous and estrous, as distinct from the control animals. Also, quinperole improved spatial learning in proestrous and stimulated it in estrous in Morris water maze. Chronic sulpiride administration similarly impaired non-spatial and spatial learning in females during all phases of ovary cycle. The results of the study suggest modulating role of D2-receptors in learning/memory processes during ovary cycle in the adult female rats.
在成年雌性大鼠中评估了D2受体在卵巢周期学习/记忆过程中的作用。将喹吡罗（0.1mg/kg，腹腔注射），一种D2受体激动剂，和舒必利（10.0mg/kg，腹腔注射），一种D2受体拮抗剂，长期注射给成年雌性大鼠。这些动物的学习能力在不同模型中进行评估：被动回避行为和莫里斯水迷宫实验。长期给雌性大鼠注射喹吡罗导致在动情前期和动情期出现被动回避行为，这与对照动物不同。此外，喹吡罗改善了动情前期的空间学习能力，并在动情期刺激了莫里斯水迷宫实验中的空间学习。长期注射舒必利同样损害了雌性大鼠在卵巢周期所有阶段的非空间和空间学习能力。该研究结果表明D2受体在成年雌性大鼠卵巢周期学习/记忆过程中具有调节作用。
