Dickerson J, Bressler R, Christian C D, Hermann H W
Clin Pharmacol Ther. 1979 Oct;26(4):502-7. doi: 10.1002/cpt1979264502.
In a double-blind parallel study daily intravaginal administration of conjugated estrogen cream and estradiol cream for 14 days relieved vasomotor and vaginal postmenopausal symptoms in 29 postmenopausal women. By day 14, therapy with the estradiol vaginal cream resulted in plasma estrone and estradiol levels closer to those in premenopausal women than therapy with the conjugated estrogen cream. The extent of improvement and final estradiol plasma levels in the estradiol vaginal-cream group correlated. There was no correlation with severity of symptoms or estradiol plasma level at baseline. The metabolism of the conjugated estrogen cream might account for absence of correlation between improvement and final estradiol plasma levels in the conjugated vaginal-cream group.
在一项双盲平行研究中，29名绝经后女性每天经阴道给予结合雌激素乳膏和雌二醇乳膏，持续14天，可缓解血管舒缩症状和绝经后阴道症状。到第14天时，与使用结合雌激素乳膏治疗相比，使用雌二醇阴道乳膏治疗使血浆雌酮和雌二醇水平更接近绝经前女性。雌二醇阴道乳膏组的改善程度与最终血浆雌二醇水平相关。与基线时的症状严重程度或血浆雌二醇水平无关。结合雌激素乳膏的代谢可能是结合阴道乳膏组改善程度与最终血浆雌二醇水平缺乏相关性的原因。
