Takahashi M, Narisawa T, Kotanagi H, Yamazaki Y, Kusaka H, Koyama K, Nakagomi O
First Department of Surgery, Akita University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1990 Oct;91(10):1554-9.
MRSA infectious diseases were often observed in our ward including general, pediatric and neurosurgery during recent two years. Following items were investigated for analysing a prevalence of the infections; 1) the frequency of MRSA in Staphylococcus aureus isolates from clinical materials, 2) the monthly number of patients with MRSA infectious diseases, 3) the biologic types and the toxigenicity of MRSA isolates from clinical materials, nasal carriers and an environmental material in the ward. The results were as follows. 1) Methicillin-cephem resistant strain was determined in 204 of 247 Staphylococcus aureus isolates (83%). 2) Monthly registration showed a trend that an increased number of the patient in one unit was followed by an increase in other units. 3) Most of MRSA isolates were classified into type II coagulase and two kinds of strains were predominantly found in isolates from clinical materials by plasmid DNA analysis. Most of MRSA isolates had capabilities of producing type C enterotoxin and toxic shock syndrome toxin-1 (TSST-1). The results suggested that the frequent MRSA infectious diseases attributed to hospital infection. Since hospital infection of virulent MRSA may cause serious infectious diseases, much concern to inhibit the spread of this organism should be required.
在过去两年中，我们科室（包括普通外科、儿科和神经外科）经常观察到耐甲氧西林金黄色葡萄球菌（MRSA）感染病例。为分析感染的流行情况，对以下项目进行了调查：1）临床材料中金黄色葡萄球菌分离株中MRSA的频率；2）每月MRSA感染疾病患者的数量；3）病房中临床材料、鼻腔携带者和环境材料中MRSA分离株的生物学类型和产毒性。结果如下：1）在247株金黄色葡萄球菌分离株中，有204株（83%）被鉴定为耐甲氧西林头孢菌素菌株；2）每月登记显示，一个科室患者数量增加后，其他科室患者数量也随之增加；3）大多数MRSA分离株被归类为II型凝固酶，通过质粒DNA分析，在临床材料分离株中主要发现两种菌株。大多数MRSA分离株具有产生C型肠毒素和毒性休克综合征毒素-1（TSST-1）的能力。结果表明，频繁发生的MRSA感染疾病归因于医院感染。由于强毒MRSA的医院感染可能导致严重的感染性疾病，因此需要高度关注抑制这种病原体的传播。
