Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
Curr Pharm Des. 2012;18(31):4865-88. doi: 10.2174/138161212803216960.
Kampo, a form of traditional herbal medical practice, has become a substance of interest for scientific research. Although earlier clinical reports concerning Kampo are abundant, the scientific investigation of Kampo has a very short history. However, the process of acquiring quantifiable clinical trial evidence on herbal medicine is now clearly underway. The development of multi-component herbal medicines capable of targeting multiple sites could be useful both for future drug discovery and for the potential management of complex diseases. Additionally, mechanistic studies and the identification of active compounds could lead to new discoveries in the biological and biomedical sciences. Modern translational research on herbal medicines beyond basic science and clinical perspectives will contribute to the development of new medicines. This review covers the translational aspects of herbal medicine with a focus on cancer anorexiacachexia. The review gives perspective on a new horizon for herbal medicine from a scientific point of view and a basis for the further development of complementary and alternative medicine (CAM) for patients.
汉方医学，一种传统的草药医疗实践形式，已成为科学研究的关注对象。虽然早期有关汉方医学的临床报告很多，但汉方医学的科学研究历史很短。然而，现在正在明确地进行获取草药临床试验证据的过程。开发能够针对多个靶点的多成分草药可能对未来的药物发现和复杂疾病的潜在管理都很有用。此外，对机制的研究和活性化合物的鉴定可能会导致生物和生物医学科学的新发现。超越基础科学和临床观点的草药的现代转化研究将有助于新药的开发。这篇综述涵盖了草药的转化方面，重点是癌症恶病质。该综述从科学角度展望了草药的新前景，并为进一步为患者开发补充和替代医学 (CAM) 提供了基础。
