Department of Emergency, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing 100044, China.
Neurophysiol Clin. 2012 Jun;42(4):241-7. doi: 10.1016/j.neucli.2012.02.136. Epub 2012 Mar 17.
To study the relationship between current perception threshold (CPT) and somatosensory evoked potential (SEP) in diabetes.
Both CPT and SEP were recorded in 66 diabetic patients. Both the CPT scores (measured at 2000 Hz, 250 Hz, and 5 Hz stimulations) and SEP (peak latency at ERB's point [Lat (ERB)] and popliteal fossa [Lat (PF)]; interpeak latency of "ERB to 7th cervical vertebra" [Δlat (ERB-C7)] and "popliteal fossa to lumbar vertebra" [Δlat (PF-FO)]) were recorded in both upper and both lower limbs, separately. t-tests and correlation analyses were performed to assess relationships between CPT and SEP tests.
After adjustment for height and/or age, CPT scores at 2000 Hz were significantly correlated with Lat (ERB) (left: ρ=0.408, P<0.05; right: ρ=0.297, P<0.05), Δlat (ERB-C7) (left: ρ=0.238, P<0.05; right: ρ=0.385, P<0.05), and Lat (PF) (ρ=0.216, P<0.05), and those at 250 Hz were moderately correlated with Lat (ERB) (left: ρ=0.234, P<0.05; right: ρ=0.306, P<0.05). CPT scores at 5 Hz were not significantly correlated with any SEP measurements (P>0.05).
Both CPT scores at 2000 Hz and SEP may reliably determine large-fiber function in diabetic neuropathy.
研究糖尿病患者的电流感觉阈值（CPT）与体感诱发电位（SEP）之间的关系。
对 66 例糖尿病患者同时进行 CPT 和 SEP 检测，分别记录双侧上下肢的 CPT 评分（2000 Hz、250 Hz 和 5 Hz 刺激）和 SEP（在 ERB 点的潜伏期[Lat（ERB）]和腘窝[Lat（PF）]；“ERB 到第 7 颈椎”[Δlat（ERB-C7）]和“腘窝到腰椎”[Δlat（PF-FO）]的峰间潜伏期）。采用 t 检验和相关分析评估 CPT 与 SEP 检测结果之间的关系。
在调整身高和/或年龄后，2000 Hz 的 CPT 评分与 Lat（ERB）（左侧：ρ=0.408，P<0.05；右侧：ρ=0.297，P<0.05）、Δlat（ERB-C7）（左侧：ρ=0.238，P<0.05；右侧：ρ=0.385，P<0.05）和 Lat（PF）（ρ=0.216，P<0.05）显著相关，250 Hz 的 CPT 评分与 Lat（ERB）（左侧：ρ=0.234，P<0.05；右侧：ρ=0.306，P<0.05）中度相关。5 Hz 的 CPT 评分与任何 SEP 测量均无显著相关性（P>0.05）。
2000 Hz 的 CPT 评分和 SEP 均可可靠地确定糖尿病周围神经病中大纤维的功能。
