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[评估化学髓核溶解术后腰椎间盘损伤的疗效]

[Evaluating performance in lumbar intervertebral disk damage following chemonucleolysis].

作者信息

von Wild K, Löchte W

机构信息

Akademisches Lehrkrankenhaus der Westfälischen Wilhelms-Universität Münster.

出版信息

Neurochirurgia (Stuttg). 1990 Sep;33(5):162-8. doi: 10.1055/s-2008-1053576.

DOI:10.1055/s-2008-1053576
PMID:2263305
Abstract

In spite of the good or excellent long-term results in 60% to 80% of the cases reported in the literature, the efficacy of the less invasive percutaneous nucleolysis in the treatment of therapy-resistant lumbar compression of the nerve root in patients with lumbar disk protrusion still remains controversial. On the one hand, there is discussion about the actual effectiveness of the enzymes injected and their local activity in bringing about the desired long-lasting nerve-root decompression. On the other hand, the presumed advantage of he method is questioned. It is said that postoperative morbidity is decreased and shortened, and that job rehabilitation is faster, especially with people performing hard physical work. More recently, the same can be said for the much-vaunted method of percutaneous automated diskectomy and nucleotomy. It was only possible to use these less invasive treatment techniques with approx. 10% of the author' patients with therapy-resistant lumbar compression syndromes of the nerve root caused by disk protrusion. In 85% of all patients treated, CNL produced a good or satisfactory result as regards the relief of sciatica and neurological disturbances. These long-term results cannot be transferred to job-rehabilitation results, as a critical review of 133 cases has shown. The authors were able to examine 108 of the 133 patients approx. one year after nucleolysis. In the group of businessmen, government officials, white-collar workers, and students, there was a correlation between long-term neurological results and job rehabilitation.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

尽管文献报道60%至80%的病例有良好或优异的长期效果,但在腰椎间盘突出症患者中,微创经皮髓核溶解术治疗耐药性腰椎神经根受压的疗效仍存在争议。一方面,对于所注射酶的实际效果及其在实现所需的持久神经根减压方面的局部活性存在讨论。另一方面,该方法假定的优势也受到质疑。据说术后发病率降低且病程缩短,工作恢复更快,尤其是从事重体力劳动的人。最近,对于备受吹嘘的经皮自动椎间盘切除术和髓核切除术也是如此。在作者治疗的因椎间盘突出导致神经根受压的耐药性腰椎综合征患者中,只有约10%的患者能够使用这些微创治疗技术。在所有接受治疗的患者中,85%的经皮髓核溶解术在缓解坐骨神经痛和神经功能障碍方面取得了良好或满意的效果。正如对133例病例的批判性回顾所示,这些长期结果不能转化为工作恢复结果。作者能够在髓核溶解术后约一年对133例患者中的108例进行检查。在商人、政府官员、白领和学生组中,长期神经学结果与工作恢复之间存在相关性。(摘要截取自250字)

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