病毒和宿主对巨细胞病毒成熟的控制。
Viral and host control of cytomegalovirus maturation.
机构信息
Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Trends Microbiol. 2012 Aug;20(8):392-401. doi: 10.1016/j.tim.2012.04.008. Epub 2012 May 23.
Abstract
Maturation in herpesviruses initiates in the nucleus of the infected cell, with encapsidation of viral DNA to form nucleocapsids, and concludes with envelopment in the cytoplasm to form infectious virions that egress the cell. The entire process of virus maturation is orchestrated by protein-protein interactions and enzymatic activities of viral and host origin. Viral tegument proteins play important roles in maintaining the structural stability of capsids and directing the acquisition of virus envelope. Envelopment occurs at modified host membranes and exploits host vesicular trafficking. In this review, we summarize current knowledge of and concepts in human cytomegalovirus (HCMV) maturation and their parallels in other herpesviruses, with an emphasis on viral and host factors that regulate this process.
摘要
疱疹病毒的成熟过程始于感染细胞的细胞核，病毒 DNA 被包裹形成核衣壳，最后在细胞质中包膜形成具有感染性的病毒粒子，从而从细胞中逸出。病毒成熟的整个过程是由病毒和宿主来源的蛋白质-蛋白质相互作用和酶活性来协调的。病毒被膜蛋白在维持衣壳的结构稳定性和指导病毒包膜的获得方面发挥重要作用。包膜发生在经过修饰的宿主膜上，并利用宿主囊泡运输。在这篇综述中，我们总结了人巨细胞病毒 (HCMV) 成熟的最新知识和概念，以及其他疱疹病毒中的相似之处，重点介绍了调节这一过程的病毒和宿主因素。
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