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Antagonists of organic anion transporters 1 and 3 ameliorate adverse cardiac remodelling induced by uremic toxin indoxyl sulfate.

作者信息

Liu Shan, Wang Bing H, Kompa Andrew R, Lekawanvijit Suree, Krum Henry

出版信息

Int J Cardiol. 2012 Jul 26;158(3):457-8. doi: 10.1016/j.ijcard.2012.05.022. Epub 2012 May 26.

DOI:10.1016/j.ijcard.2012.05.022
PMID:22633673
Abstract
摘要

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1
Antagonists of organic anion transporters 1 and 3 ameliorate adverse cardiac remodelling induced by uremic toxin indoxyl sulfate.
Int J Cardiol. 2012 Jul 26;158(3):457-8. doi: 10.1016/j.ijcard.2012.05.022. Epub 2012 May 26.
2
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.有机阴离子转运体3在肾脏中硫酸吲哚酚转运中的主要作用。
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Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity.有机阴离子转运体在硫酸吲哚酚肾小管转运及其肾毒性诱导中的作用。
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Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2.降尿酸药物通过抑制肾脏转运体 OAT1/3 和 ABCG2 减少吲哚硫酸酯的排泄。
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Organic anion transporters involved in the excretion of bestatin in the kidney.参与贝他斯汀在肾脏中排泄的有机阴离子转运体。
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A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.大鼠和人类肾脏有机阴离子及阳离子转运体对H2受体拮抗剂转运活性的种属差异。
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Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters.利用稳定表达人类有机阴离子转运体的细胞对有机阴离子转运抑制剂进行表征。
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Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3.前列腺素E2通过下调有机阴离子转运蛋白rOAT1和rOAT3来抑制其自身的肾脏转运。
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Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?硫酸吲哚酚，一种尿毒症毒素，对心肌成纤维细胞和心肌细胞是否有直接作用？
Eur Heart J. 2010 Jul;31(14):1771-9. doi: 10.1093/eurheartj/ehp574. Epub 2010 Jan 4.

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