Research Center for Environmental Science and Engineering, Shanxi University, 030006, Taiyuan, China.
Sci Total Environ. 2012 Jul 15;430:75-81. doi: 10.1016/j.scitotenv.2012.04.040. Epub 2012 May 24.
There are few longitudinal studies on health effects of dampness and moulds in workplace buildings. We studied associations between dampness and indoor moulds in workplace buildings and selected biomarkers as well as incidence and remission of sick building syndrome (SBS). The study was based on a ten-year prospective study (1992-2002) in a random sample of adults (N=429) from the Uppsala part of the European Community Respiratory Health Survey (ECRHS). The 10-year incidence (onset) of general, mucosal, dermal symptoms and any symptom improved when away from the workplace (work-related symptoms) was 7.2%, 11.6%, 6.4% and 9.4% respectively. The 10-year remission of general, mucosal, dermal symptoms and work-related symptoms was 71.4%, 57.1%, 70.4% and 72.2% respectively. Signs of dampness in the floor construction in any workplace building during follow up (cumulative exposure) was associated with incidence of mucosal symptoms (OR=2.43). Cumulative exposure to moldy odor was associated with incidence of work-related symptoms (OR=2.69). Cumulative exposure to dampness or moulds was associated with decreased remission of work-related symptoms (OR=0.20 for water leakage, OR=0.17 for floor dampness, and OR=0.17 for visible indoor mould growth). Working in a building repaired because of dampness (repaired building) or mould was associated with decreased remission of work-related symptoms (OR=0.32). Any dampness or moulds at baseline in the workplace building was associated with increased bronchial responsiveness (BR) and higher levels of Eosinphilic Cationic Protein (ECP) in serum and Eosinophilic counts in blood at baseline. Cumulative exposure to dampness and moulds, and work in a repaired building, was associated with increased BR at follow-up. In general, dampness and moulds in the workplace building is associated with increased incidence and decreased remission of SBS, as well as increased bronchial responsiveness and eosinophilic inflammation.
关于工作场所建筑物中的潮湿和霉菌对健康的影响，目前很少有纵向研究。我们研究了工作场所建筑物中的潮湿和室内霉菌与选择生物标志物以及病态建筑综合征（SBS）的发生率和缓解率之间的关联。该研究基于对欧洲社区呼吸健康调查（ECRHS）乌普萨拉部分的随机成人样本（N=429）进行的为期十年的前瞻性研究（1992-2002 年）。一般、黏膜、皮肤症状和远离工作场所时的任何症状（工作相关症状）的 10 年发生率（发病）分别为 7.2%、11.6%、6.4%和 9.4%。一般、黏膜、皮肤症状和工作相关症状的 10 年缓解率分别为 71.4%、57.1%、70.4%和 72.2%。在随访期间（累积暴露），任何工作场所建筑物地板结构中的潮湿迹象与黏膜症状的发生率相关（OR=2.43）。发霉气味的累积暴露与工作相关症状的发生率相关（OR=2.69）。潮湿或霉菌的累积暴露与工作相关症状缓解率降低相关（OR=0.20 与漏水有关，OR=0.17 与地板潮湿有关，OR=0.17 与可见室内霉菌生长有关）。在因潮湿（修复建筑物）或霉菌而修复的建筑物中工作与工作相关症状的缓解率降低相关（OR=0.32）。工作场所建筑物中基线时存在任何潮湿或霉菌与支气管高反应性（BR）增加以及血清中嗜酸性阳离子蛋白（ECP）水平和血液中嗜酸性粒细胞计数增加相关。潮湿和霉菌的累积暴露以及在修复建筑物中工作与随访时 BR 增加相关。总的来说，工作场所建筑物中的潮湿和霉菌与 SBS 的发生率增加和缓解率降低有关，以及支气管高反应性和嗜酸性粒细胞炎症增加有关。
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