Guarda L A, Borrero J L
Department of Pathology, Florida Hospital.
Mod Pathol. 1990 Nov;3(6):654-8.
Twenty young adult patients with hand and digital ischemia were found to have obstructive arterial disease. All patients were surgically explored, and the occluded vessels were resected and by-passed. Eighteen patients had obstruction at the level of the distal ulnar artery and palmar arch, and 12 had obstruction of the common digital and digital proper arteries. Occlusive arteriosclerotic lesions were found in all patients; these lesions were characterized by prominent fibromuscular intimal plaques with superimposed thrombosis. Six patients had also thromboembolism to distal digital vessels. Vasculitis, calcifications, cholesterol deposits, and atheromatous emboli were not observed. Five patients had transmural neovascularization of the lesions in a similar manner to that described in coronary artery lesions. Obstructive lesions due to fibromuscular intimal proliferation with associated thrombosis and/or distal thromboembolization affecting arteries of hands and digits appear to be an important lesion that can affect young patients.
二十名患有手部和手指缺血的年轻成年患者被发现患有阻塞性动脉疾病。所有患者均接受了手术探查，闭塞的血管被切除并进行了搭桥。18名患者在尺动脉远端和掌弓水平出现阻塞，12名患者的指总动脉和指固有动脉出现阻塞。所有患者均发现闭塞性动脉硬化病变；这些病变的特征是突出的纤维肌性内膜斑块并伴有血栓形成。6名患者还出现了远端指血管的血栓栓塞。未观察到血管炎、钙化、胆固醇沉积和动脉粥样硬化栓子。5名患者的病变出现了透壁新生血管形成，其方式与冠状动脉病变中描述的相似。由纤维肌性内膜增生伴相关血栓形成和/或影响手部和手指动脉的远端血栓栓塞引起的阻塞性病变似乎是一种可影响年轻患者的重要病变。
