Maskrey M, Megirian D, Sherrey J H
Department of Physiology, Faculty of Medicine, University of Tasmania, Hobart, Australia.
Respir Physiol. 1990 Aug;81(2):203-12. doi: 10.1016/0034-5687(90)90046-2.
The respiratory rate (f), tidal volume (VT) and ventilation (V) were measured in 3 groups of rats: 10 rats before and after cutting both recurrent laryngeal nerves (RLNX), 10 rats before and after bilateral phrenicotomy (PNX) and 5 sham transected (SHAMX) rats. All rats were exposed to air and gas mixtures, deficient in O2 and/or enriched with CO2. The barometric method was used to measure ventilatory parameters. The sham operation did not affect breathing pattern or ventilation. In RLNX rats, breathing the various gas mixtures exhibited no changes in V because f uniformly increased as VT declined. Therefore, loss of the neural control of the respiratory functions of the larynx in awake rats exposed to selected gas mixtures has no untoward effects on alveolar ventilation. Changes in ventilation of PNX rats, compared with SHAMX rats, depends on the gas composition breathed. With increasing severity of hypoxia and/or hypercapnia, PNX rats show a marked reduction in alveolar ventilation over that of the SHAMX rats. Thus, when the diaphragm is no longer able to participate in ventilatory responses, gas exchange is likely to become deficient.
对三组大鼠的呼吸频率（f）、潮气量（VT）和通气量（V）进行了测量：10只大鼠在双侧喉返神经切断术（RLNX）前后，10只大鼠在双侧膈神经切断术（PNX）前后，以及5只假切断（SHAMX）大鼠。所有大鼠均暴露于氧气不足和/或二氧化碳富集的空气和气体混合物中。采用气压法测量通气参数。假手术不影响呼吸模式或通气。在RLNX大鼠中，呼吸各种气体混合物时V没有变化，因为随着VT下降f均匀增加。因此，在暴露于特定气体混合物的清醒大鼠中，喉部呼吸功能的神经控制丧失对肺泡通气没有不良影响。与SHAMX大鼠相比，PNX大鼠的通气变化取决于所呼吸的气体成分。随着缺氧和/或高碳酸血症严重程度的增加，PNX大鼠的肺泡通气量比SHAMX大鼠显著降低。因此，当膈肌不再能够参与通气反应时，气体交换可能会不足。
