S-腺苷-L-蛋氨酸对肝性卟啉病的保护作用。在实验模型中的评估。

Protective effect of S-adenosyl-L-methionine in hepatic uroporphyria. Evaluation in an experimental model.

作者信息

Cantoni L, Budillon G, Cuomo R, Rodinò S, Le Grazie C, Di Padova C, Rizzardini M

机构信息

Mario Negri Pharmacologic Research Institute and BioResearch S.p.A., Milan, Italy.

出版信息

Scand J Gastroenterol. 1990 Oct;25(10):1034-40. doi: 10.3109/00365529008997631.

DOI:10.3109/00365529008997631

PMID:2263875

Abstract

The potential use of S-adenosyl-L-methionine (SAMe) as therapy for human porphyria cutanea tarda was investigated in an experimental model of hepatic porphyria--that is, chronic treatment of female rats with 0.2% hexachlorobenzene (HCB) in the diet. Administration of SAMe (25 mg/kg subcutaneously twice daily) during the last 15 days of HCB administration halved porphyrin accumulation in the liver but did not alter HCB-induced massive inhibition of uroporphyrinogen decarboxylase. Equally unaffected were inhibition of glutathione peroxidase and stimulation of lipid peroxide formation induced by HCB. Hypothetically, the beneficial effect of SAMe on hepatic porphyrin accumulation might be linked to modifications of the cellular availability of adenosine triphosphate.

摘要

在肝性卟啉症的实验模型中，研究了S-腺苷-L-甲硫氨酸（SAMe）作为人类迟发性皮肤卟啉症治疗方法的潜在用途。该实验模型是通过在雌性大鼠的饮食中添加0.2%的六氯苯（HCB）进行慢性处理。在给予HCB的最后15天期间，皮下注射SAMe（25mg/kg，每日两次）可使肝脏中的卟啉积累减半，但并未改变HCB诱导的尿卟啉原脱羧酶的大量抑制。同样未受影响的还有HCB诱导的谷胱甘肽过氧化物酶抑制和脂质过氧化物形成的刺激。假设SAMe对肝脏卟啉积累的有益作用可能与三磷酸腺苷细胞可用性的改变有关。