Division of Biology, California Institute of Technology, Pasadena, California, USA.
Dev Dyn. 2012 Aug;241(8):1325-32. doi: 10.1002/dvdy.23809. Epub 2012 Jun 15.
The neural crest is a multipotent cell type unique to the vertebrate lineage and capable of differentiating into a large number of varied cell types, including ganglia of the peripheral nervous system, cartilage, and glia. An early step in neural crest specification occurs at the neural plate border, a region defined by the overlap of transcription factors of the Zic, Msx, and Pax families.
Here we identify a novel chick gene with close homology to double-stranded RNA-binding protein Interleukin enhancer binding factor 3 (ILF-3) in other species. Our results show that chick Ilf-3 is required for proper expression of the transcription factor, Zic-1, at the neural plate border.
We have identified a novel chick gene and show it has a role in the correct specification of Zic-1 at the neural plate border.
神经嵴是脊椎动物谱系中特有的多能细胞类型，能够分化为多种不同的细胞类型，包括外周神经系统的神经节、软骨和神经胶质。神经嵴特化的早期步骤发生在神经板边界，该区域由 Zic、Msx 和 Pax 家族转录因子的重叠定义。
在这里，我们在鸡中鉴定出了一个与其他物种中双链 RNA 结合蛋白白细胞介素增强子结合因子 3（ILF-3）具有密切同源性的新基因。我们的结果表明，鸡 Ilf-3 是神经板边界处转录因子 Zic-1 正确表达所必需的。
我们已经鉴定出一个新的鸡基因，并表明它在神经板边界处正确特化 Zic-1 中具有作用。
