Reichen J, Paumgartner G
Experientia. 1979 Sep 15;35(9):1186-8. doi: 10.1007/BF01963278.
Na +, K + -adenosinetriphosphatase (Na +, K + -ATPase) activity was decreased in liver plasma membranes from rats in which cholestasis had been induced by i.v. administration of sodium taurolithocholate (5 mumoles/100 g b. wt). Incubation of liver plasma membranes with taurolithocholate (10--1300 muM) caused significant and dose dependent reductions of Na +, K + -ATPase activity at taurolithocholate concentrations above 100 muM. These findings lend support to the hypothesis that cholestasis induced by monohydroxy bile acids is at least partially the result of an inhibition of hepatic Na +, K + -ATPase activity.
通过静脉注射牛磺石胆酸钠（5微摩尔/100克体重）诱导胆汁淤积的大鼠肝细胞膜中，钠钾-三磷酸腺苷酶（Na +, K + -ATP酶）活性降低。用牛磺石胆酸钠（10 - 1300微摩尔）孵育肝细胞膜，当牛磺石胆酸钠浓度高于100微摩尔时，会导致Na +, K + -ATP酶活性显著且呈剂量依赖性降低。这些发现支持了以下假说：单羟基胆汁酸诱导的胆汁淤积至少部分是肝Na +, K + -ATP酶活性受到抑制的结果。
