Ding H, Zhou Q, Deng J, Lo H Y, Yang K
Department of Physiology, Tongji Medical University, Wuhan, Hubei.
Sheng Li Xue Bao. 1990 Aug;42(4):379-84.
The content of norepinephrine (NE) and epinephrine (E) in the brain of spontaneously hypertensive rats has proved abnormal, but the cause remained unknown. It was shown in the recent work that NE content in pons, posterior hypothalamus, nucleus caudatus and E concentration in medulla oblongata, anterior and posterior hypothalamus of 12-week old stroke-prone spontaneously hypertensive rats (SHRSP) were much higher than those of age-matched Wister-Kyoto rats (WKY). SHRSP also showed higher levels of systolic blood pressure (SBP) and brain angiotensin II (A II) than WKY. Intracerebroventricular (icv) perfusion of angiotensin-converting enzyme inhibitor captopril (20 micrograms for each time and three times for each day for four weeks) inhibited the synthesis of brain A II and reduced SBP and NE, E contents in all examined brain areas in SHRSP and WKY. However, the effects of chronically perfused captopril on SBP and brain NE, E levels in SHRSP were much more significant than in WKY. The results indicate that the modulatory effects of central renin-angiotensin system (RAS) on central adrenergic and noradrenergic system might be overactivated in SHRSP, which might partially responsible for the abnormally high levels of NE, E in some of the brain areas of SHRSP.
自发性高血压大鼠脑内去甲肾上腺素（NE）和肾上腺素（E）的含量已被证实存在异常，但原因尚不清楚。最近的研究表明，12周龄的易中风自发性高血压大鼠（SHRSP）脑桥、下丘脑后部、尾状核中的NE含量以及延髓、下丘脑前部和后部中的E浓度均显著高于同龄的Wister-Kyoto大鼠（WKY）。SHRSP的收缩压（SBP）和脑内血管紧张素II（A II）水平也高于WKY。脑室内（icv）灌注血管紧张素转换酶抑制剂卡托普利（每次20微克，每天3次，持续4周）可抑制SHRSP和WKY脑内A II的合成，并降低SBP以及所有检测脑区中的NE、E含量。然而，长期灌注卡托普利对SHRSP的SBP以及脑内NE、E水平的影响比对WKY的影响更为显著。结果表明，中枢肾素-血管紧张素系统（RAS）对中枢肾上腺素能和去甲肾上腺素能系统的调节作用在SHRSP中可能过度激活，这可能是导致SHRSP某些脑区中NE、E水平异常升高的部分原因。
