Department of Biology, University of Missouri St. Louis, MO, USA.
Front Plant Sci. 2012 Mar 19;3:51. doi: 10.3389/fpls.2012.00051. eCollection 2012.
The activation of phospholipase D (PLD) produces phosphatidic acid (PA), whereas plant sphingosine kinase (SPHK) phosphorylates long-chain bases to generate long-chain base-1-phosphates such as phytosphingosine-1-phosphate (phyto-S1P). PA and phyto-S1P have been identified as lipid messengers. Recent studies have shown that PA interacts directly with SPHKs in Arabidopsis, and that the interaction promotes SPHK activity. However, SPHK and phyto-S1P act upstream of PLDα1 and PA in the stomatal response to abscisic acid (ABA). These findings indicate that SPHK/phyto-S1P and PLD/PA are co-dependent in the amplification of lipid messengers, and that crosstalk between the sphingolipid- and phospholipid-mediated signaling pathways may play important roles in plant stress signaling.
磷脂酶 D（PLD）的激活产生了磷酸脂酰甘油（PA），而植物鞘氨醇激酶（SPHK）则将长链碱基磷酸化生成长链碱基-1-磷酸，如植物鞘氨醇-1-磷酸（phyto-S1P）。PA 和 phyto-S1P 已被鉴定为脂质信使。最近的研究表明，PA 在拟南芥中直接与 SPHK 相互作用，并且这种相互作用促进了 SPHK 活性。然而，SPHK 和 phyto-S1P 在脱落酸（ABA）诱导的气孔反应中位于 PLDα1 和 PA 的上游。这些发现表明，SPHK/phyto-S1P 和 PLD/PA 在脂质信使的放大中是相互依赖的，鞘脂和磷脂介导的信号通路之间的串扰可能在植物应激信号中发挥重要作用。
