Feasibility study of paclitaxel plus carboplatin in patients with endometrial cancer: a Japan Kanto Tumor Board study (JKTB trial).
作者信息
Yamada Kyosuke, Tanabe Hiroshi, Imai Manami, Jobo Toshiko, Kudo Kazuya, Fujiwara Hiroyuki, Nagata Chie, Furuya Kenichi, Suzuki Mitsuaki, Ochiai Kazunori, Tanaka Tadao, Yasuda Makoto
机构信息
Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Minato-ku Azabu-juban Manami Women's Clinic, Minato-ku, Tokyo, Japan.
出版信息
J Obstet Gynaecol Res. 2013 Jan;39(1):311-6. doi: 10.1111/j.1447-0756.2012.01890.x. Epub 2012 May 28.
AIM
The optimal chemotherapy regimen for patients with endometrial cancer has not been established. We assessed the feasibility of paclitaxel plus carboplatin (TC) for postoperative chemotherapy in patients with endometrial cancer.
MATERIAL AND METHODS
Patients with newly diagnosed endometrial cancer received TC (paclitaxel 180 mg/m(2) , carboplatin AUC6 mg/mL/min) every three weeks. Treatment was continued until disease progression or completion of six cycles. Toxicities were evaluated every cycle according to NCI-CTCAE version 3.0.
RESULTS
Sixty patients were registered from December 2005 through November 2006. Forty-four of 60 (73.3%) cases completed all of the planned six cycles. Grades 3 and 4 hematologic toxicities were observed as follows: leukopenia (61.7%), neutropenia (95.0%), anemia (21.7%), and thrombocytopenia (5.0%). There were six patients who dropped out from the protocol by neutropenia. Grade 3 non-hematologic toxicities were observed as follows: nausea (3.3%), vomiting (1.7%), neuropathy (5.0%), myalgia (6.7%) and constipation (1.7%). No grade 4 non-hematologic toxicity was observed.
CONCLUSION
This TC regimen is feasible for endometrial cancer patients.
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