Department of Pharmaceutics, Shree Santkrupa College of Pharmacy, Karad, India.
Drug Dev Ind Pharm. 2013 May;39(5):716-23. doi: 10.3109/03639045.2012.689764. Epub 2012 May 29.
The objective of present investigation was to evaluate performance of cocrystals of Mefloquine Hydrochloride (MFL) in tablet dosage form. Our previous investigation showed significant effect of cocrystal formers on improving the solubility and dissolution rate of Mefloquine hydrochloride by cocrystallization method when prepared by solution cocrystallization method.
Prepared cocrystals of MFL with different ratio of cocrystal formers were incorporated in tablet dosage form and evaluated for micrometric properties, drug content, hardness, disintegration test, vitro dissolution studies and stability studies. Performance was compared with laboratory prepared tablet of MFL 250 mg.
The considerable improvement in the dissolution rate was observed in case of cocrystals based tablets than pure MFL tablets.
So we can incorporate cocrystals in tablet dosage form to enhance in vitro and in vivo performance. To the best of our knowledge, this is the first report, cocrystals has been evaluated in tablet dosage form.
本研究的目的是评估盐酸甲氟喹（MFL）共晶在片剂中的性能。我们之前的研究表明，共晶形成剂通过溶液共晶化法制备共晶时，对改善盐酸甲氟喹的溶解度和溶出速率有显著影响。
将不同比例的共晶形成剂制备的 MFL 共晶掺入片剂中，并对其进行微观性质、药物含量、硬度、崩解试验、体外溶出度研究和稳定性研究。并与实验室制备的 250mg MFL 片剂进行比较。
共晶片的溶出速率有明显提高。
因此，我们可以将共晶掺入片剂中，以提高体外和体内性能。据我们所知，这是首次将共晶评价为片剂剂型。
