治疗儿童原发性恶性肿瘤后中枢神经系统继发性肿瘤的回顾。

A review of secondary central nervous system tumors after treatment of a primary pediatric malignancy.

机构信息

Department of Hematology/Oncology, Children's National Medical Center, Washington, DC, USA.

出版信息

Semin Pediatr Neurol. 2012 Mar;19(1):43-8. doi: 10.1016/j.spen.2012.02.015.

DOI:10.1016/j.spen.2012.02.015

Abstract

Despite remarkable strides in the treatment of pediatric malignancies over the last 50 years, long-lasting sequelae and secondary malignancies continue to plague this population. This article reviews the incidence, diagnosis, and etiology of secondary central nervous system tumors in the setting of a history of primary pediatric malignancy. Particular attention is paid to central nervous system tumors presenting after treatment of leukemia and primary brain tumors, as well as the role of treatment and underlying cancer predisposition syndromes in the risk of developing these secondary tumors.

摘要

尽管在过去的 50 年中，儿科恶性肿瘤的治疗取得了显著进展，但长期的后遗症和继发性恶性肿瘤仍然困扰着这一人群。本文回顾了原发性儿科恶性肿瘤治疗后发生的继发性中枢神经系统肿瘤的发病率、诊断和病因。特别关注白血病和原发性脑肿瘤治疗后出现的中枢神经系统肿瘤，以及治疗和潜在的癌症易患综合征在这些继发性肿瘤发生风险中的作用。