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荧光查尔酮库的开发及其在发现小鼠胚胎干细胞探针中的应用。

Development of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe.

机构信息

Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Biopolis, Singapore 138667.

出版信息

Chem Commun (Camb). 2012 Jul 7;48(53):6681-3. doi: 10.1039/c2cc31662e. Epub 2012 May 29.

DOI:10.1039/c2cc31662e
PMID:22641464
Abstract

We report the first fluorescent diamino-chalcone library and its application in the discovery of a mouse embryonic stem cell (mESC) probe. CDg4, a novel green fluorescent mESC probe was discovered through a high-content image based screening of 160 members of the chalcone library. Interestingly, the molecular binding target of CDg4 was identified as the glycogen of the stem cell colony surface, rather than a conventional protein target from an intracellular source.

摘要

我们报告了第一个荧光二氨基查尔酮库及其在发现小鼠胚胎干细胞 (mESC) 探针中的应用。通过对查尔酮库的 160 个成员进行高内涵图像筛选，发现了一种新型绿色荧光 mESC 探针 CDg4。有趣的是，CDg4 的分子结合靶标被鉴定为干细胞集落表面的糖原，而不是来自细胞内源的传统蛋白质靶标。

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