Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.
J Biochem. 2012 Jul;152(1):1-3. doi: 10.1093/jb/mvs057. Epub 2012 May 28.
Maintenance of undifferentiated states of pluripotent embryonic stem cells is regulated by a complex network of transcription factors and signaling pathways. Recent reports revealed that developmental pluripotency-associated 2 (Dppa2), which regulates chromatin structures, plays important roles in the maintenance of pluripotency and proliferation of embryonic stem cells. Interestingly, developmental pluripotency-associated 2 is involved not only in the normal development of lung but also in the pathogenesis of non-small cell lung cancers. These results suggest that an epigenetic regulator of pluripotent stem cells plays important roles in normal development and tumorigenesis.
多能胚胎干细胞的未分化状态的维持受转录因子和信号通路的复杂网络调控。最近的研究报告表明，发育多能性相关蛋白 2（Dppa2），它调节染色质结构，在胚胎干细胞的多能性维持和增殖中发挥重要作用。有趣的是，发育多能性相关蛋白 2不仅参与肺的正常发育，而且参与非小细胞肺癌的发病机制。这些结果表明多能干细胞的表观遗传调节剂在正常发育和肿瘤发生中起重要作用。
