Barri M E, el Dirdiri N I, Abu Damir H, Idris O F
Veterinary Research Administration, El Amarat, Khartoum, Sudan.
Vet Hum Toxicol. 1990 Dec;32(6):541-5.
Eight Nubian goats were given Abrus precatorius seed at 2, 1 and 0.5 g/kg/day by stomach tube. Six goats receiving the plant seed at 2 and 1 g/kg died between days 2 and 5. One goat receiving Abrus seed at 0.5 g/kg/day died on day 32 and the other animal in the group was killed on day 33. The main signs of Abrus poisoning were inappetence, bloody diarrhea, dyspnea, dehydration, loss of condition and recumbency. The lesions were fatty change and necrosis of hepatocytes and renal convoluted tubules, pulmonary hemorrhage, edema and emphysema, and erosions of the abomasal and intestinal epithelium. These changes were accompanied by increases in GOT and gamma GT activities and urea, creatinine, sodium and potassium and by decreases in total protein and albumin in the serum of Abrus-poisoned goats. The blood cell changes indicated hemoconcentration.
八只努比亚山羊通过胃管分别以2克/千克/天、1克/千克/天和0.5克/千克/天的剂量投喂相思子种子。六只以2克/千克和1克/千克剂量接受植物种子投喂的山羊在第2天至第5天之间死亡。一只以0.5克/千克/天剂量接受相思子种子投喂的山羊在第32天死亡，该组中的另一只动物在第33天被处死。相思子中毒的主要症状为食欲不振、血性腹泻、呼吸困难、脱水、体重减轻和卧地不起。病变包括肝细胞和肾曲小管的脂肪变性和坏死、肺出血、水肿和气肿，以及皱胃和肠上皮的糜烂。这些变化伴随着相思子中毒山羊血清中谷草转氨酶（GOT）、γ-谷氨酰转移酶（gamma GT）活性以及尿素、肌酐、钠和钾含量的升高，以及总蛋白和白蛋白含量的降低。血细胞变化表明血液浓缩。
