Ahmed K E, Adam S E, Idrill O F, Wahbi A A
Department of Biochemistry, Nutrition and Toxicology, Veterinary Research, Administration, Khartoum.
Vet Hum Toxicol. 1990 Jun;32(3):249-51.
The toxicity of sodium selenite was studied in 28 Nubian goats, 20 of which died or were killed in extremis 2 h to 21 d after dosing. Single or repeated daily oral doses of 160, 80, 40, 20 and 5 mg sodium selenite/kg were toxic to goats while daily doses of selenite ranging from 0.25 to 1 mg/kg/d for 225 d were not toxic to this species of animals. The main signs of poisoning were uneasiness, inappetence, dyspnea, salivation, diarhea, paresis of the hind limbs, arching of the back, and recumbency. The main lesions were hemorrhages in the rumen, reticulum, osmasum and abomasum, hemorrhagic or catarrhal abomasitis and enteritis, fatty change and necrosis of the centrilobular hepatocytes and of the cells of the renal convoluted tubules, splenic hemosiderosis, pulmonary congestion, haemorrhage, edema and emphysema, accumulation of lymphocytes in the vital organs, and straw-colored fluid in the serous cavities.
对28只努比亚山羊进行了亚硒酸钠毒性研究，其中20只在给药后2小时至21天内死亡或濒死。每日单次或重复口服160、80、40、20和5毫克亚硒酸钠/千克对山羊有毒，而每日剂量为0.25至1毫克/千克/天，持续225天对该物种动物无毒。中毒的主要症状为不安、食欲不振、呼吸困难、流涎、腹泻、后肢麻痹、背部拱起和卧地不起。主要病变为瘤胃、网胃、瓣胃和皱胃出血，出血性或卡他性皱胃炎和肠炎，小叶中心肝细胞和肾曲管细胞的脂肪变性和坏死，脾含铁血黄素沉着，肺充血、出血、水肿和气肿，重要器官淋巴细胞积聚，浆膜腔积液呈稻草色。
