脓毒症的历史沿革
A historical perspective on sepsis.
机构信息
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-5602, USA.
出版信息
Am J Pathol. 2012 Jul;181(1):2-7. doi: 10.1016/j.ajpath.2012.05.003. Epub 2012 May 26.
Abstract
In North America, approximately 700,000 cases of sepsis occur each year, with mortality ranging between 30% and 50%. The American Journal of Pathology has featured numerous articles on the topic, revealing mechanistic insights gleaned from both experimental rodent models and human sepsis. Nonetheless, there remains urgent need to determine the basis for sepsis-related complications and how they can be avoided, as well as how they can be most effectively treated once recognized. This historical perspective reviews what we currently understand about the mechanisms of sepsis, as well as the barriers that remain in our treatment strategies.
摘要
在北美，每年大约有 70 万例脓毒症病例，死亡率在 30%至 50%之间。《美国病理学杂志》上刊登了许多关于这一主题的文章，揭示了从实验性啮齿动物模型和人类脓毒症中获得的机制见解。尽管如此，仍迫切需要确定与脓毒症相关的并发症的基础以及如何避免这些并发症，以及一旦识别出这些并发症，如何最有效地治疗这些并发症。本历史观点回顾了我们目前对脓毒症机制的理解，以及我们在治疗策略中仍然存在的障碍。
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