Department of Medical Physics, Royal Adelaide Hospital Cancer Centre, South Australia, Australia.
Phys Med Biol. 2012 Jun 21;57(12):3853-68. doi: 10.1088/0031-9155/57/12/3853. Epub 2012 May 30.
Optical CT scanners for a 3D readout of externally irradiated radiosensitive hydrogels currently require the use of a refractive index (RI) matching liquid bath to obtain suitable optical ray paths through the gel sample to the detector. The requirement for a RI matching liquid bath has been negated by the design of a plastic cylindrical gel container that provides parallel beam geometry through the gel sample for the majority of the projection. The design method can be used for various hydrogels. Preliminary test results for the prototype laser beam scanner with ferrous xylenol-orange gel show geometric distortion of 0.2 mm maximum, spatial resolution limited to beam spot size of about 0.4 mm and 0.8% noise (1 SD) for a uniform irradiation. Reconstruction of a star pattern irradiated through the cylinder walls demonstrates the suitability for external beam applications. The extremely simple and cost-effective construction of this optical CT scanner, together with the simplicity of scanning gel samples without RI matching fluid increases the feasibility of using 3D gel dosimetry for clinical external beam dose verifications.
目前,用于 3D 读取外部辐射敏感染胶片的光学 CT 扫描仪需要使用折射率(RI)匹配液浴来获得穿过凝胶样本到达探测器的合适光线路径。通过设计一个提供平行光束几何形状的塑料圆柱形凝胶容器,该设计消除了对 RI 匹配液浴的要求,该容器可用于大多数投影。该设计方法可用于各种水凝胶。原型激光束扫描仪用亚铁二甲酚橙凝胶进行的初步测试结果表明,最大几何变形为 0.2mm,空间分辨率限于约 0.4mm 的光束光斑大小,对于均匀照射,噪声为 0.8%(1 SD)。通过圆柱体壁照射的星形图案的重建证明了其适用于外束应用。这种光学 CT 扫描仪的结构极其简单且具有成本效益,而且无需 RI 匹配流体即可扫描凝胶样本,这增加了使用 3D 凝胶剂量测量进行临床外束剂量验证的可行性。