Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, P.O. Box 85500, GA Utrecht 3508, The Netherlands.
Br J Cancer. 2012 Jun 26;107(1):161-4. doi: 10.1038/bjc.2012.245. Epub 2012 May 29.
It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management.
We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008.
About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR=1.04 per year 95% CI (1.03-1.06)), sarcomatoid subtype (HR=2.45 95% CI (2.06-2.90)) and non-pleural localisation (HR=1.67 95% CI (1.26-2.22)).
Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis.
定期更新恶性间皮瘤患者的生存估计非常重要，因为预后可能因流行病学因素以及诊断和治疗管理而有所不同。
我们评估了 2005 年至 2008 年间确诊为恶性间皮瘤的 1353 例患者的总体（基线）生存率以及相关预后变量。
约 50%的患者在诊断时年龄为 70 岁或以上，石棉暴露起始后中位潜伏期为 49 年。诊断后 1 年，47%的患者存活，2 年后 20%，3 年后 15%。与生存较差相关的独立预后因素包括：年龄较大（每增加 1 岁，HR=1.04；95%CI：1.03-1.06）、肉瘤样亚型（HR=2.45；95%CI：2.06-2.90）和非胸膜定位（HR=1.67；95%CI：1.26-2.22）。
恶性间皮瘤患者的生存仍然有限，高度取决于患者年龄、间皮瘤亚型和定位。此外，相当一部分患者在石棉暴露和诊断之间存在较长的潜伏期。
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