• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种基于碳点的可调比率型 pH 传感器，用于定量测量全细胞的细胞内 pH 值。

A tunable ratiometric pH sensor based on carbon nanodots for the quantitative measurement of the intracellular pH of whole cells.

机构信息

Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

出版信息

Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6432-5. doi: 10.1002/anie.201202533. Epub 2012 May 29.

DOI:10.1002/anie.201202533
PMID:22644672
Abstract

The whole picture: Carbon nanodots labeled with two fluorescent dyes have been developed as a tunable ratiometric pH sensor to measure intracellular pH. The nanosensor shows good biocompatibility and cellular dispersibility. Quantitative determinations on intact HeLa cells and pH fluctuations associated with oxidative stress were performed.

摘要

整体情况

已开发出用两种荧光染料标记的碳纳米点作为可调比率比色 pH 传感器，以测量细胞内 pH。该纳米传感器具有良好的生物相容性和细胞分散性。对完整的 HeLa 细胞进行了定量测定，并检测了与氧化应激相关的 pH 波动。

相似文献

1
A tunable ratiometric pH sensor based on carbon nanodots for the quantitative measurement of the intracellular pH of whole cells.一种基于碳点的可调比率型 pH 传感器，用于定量测量全细胞的细胞内 pH 值。
Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6432-5. doi: 10.1002/anie.201202533. Epub 2012 May 29.
2
A low cytotoxic and ratiometric fluorescent nanosensor based on carbon-dots for intracellular pH sensing and mapping.一种基于碳点的低细胞毒性和比率荧光纳米传感器，用于细胞内 pH 感测和成像。
Nanotechnology. 2013 Sep 13;24(36):365101. doi: 10.1088/0957-4484/24/36/365101. Epub 2013 Aug 13.
3
Evaluating nanoparticle sensor design for intracellular pH measurements.评估用于细胞内 pH 测量的纳米粒子传感器设计。
ACS Nano. 2011 Jul 26;5(7):5864-73. doi: 10.1021/nn201643f. Epub 2011 Jul 6.
4
Localized intracellular pH measurement using a ratiometric photoinduced electron-transfer-based nanosensor.使用基于比率光诱导电子转移的纳米传感器进行局部细胞内pH测量。
Angew Chem Int Ed Engl. 2012 Sep 17;51(38):9657-61. doi: 10.1002/anie.201203866. Epub 2012 Aug 21.
5
A hydrogel based nanosensor with an unprecedented broad sensitivity range for pH measurements in cellular compartments.一种基于水凝胶的纳米传感器，在细胞区室的pH测量中具有前所未有的广泛灵敏度范围。
Analyst. 2015 Nov 7;140(21):7246-53. doi: 10.1039/c5an01014d.
6
Improving the biocompatibility of carbon nanodots for cell imaging.提高用于细胞成像的碳纳米点的生物相容性。
Talanta. 2016 Dec 1;161:54-61. doi: 10.1016/j.talanta.2016.08.031. Epub 2016 Aug 9.
7
A nanogel for ratiometric fluorescent sensing of intracellular pH values.一种用于细胞内pH值比率荧光传感的纳米凝胶。
Angew Chem Int Ed Engl. 2010 Jun 7;49(25):4246-9. doi: 10.1002/anie.200906926.
8
Self-assembled supramolecular nanoprobes for ratiometric fluorescence measurement of intracellular pH values.用于细胞内pH值比率荧光测量的自组装超分子纳米探针。
Anal Chem. 2015 Feb 17;87(4):2459-65. doi: 10.1021/ac504458r. Epub 2015 Feb 3.
9
Fluorescent push-pull pH-responsive probes for ratiometric detection of intracellular pH.用于比率检测细胞内pH值的荧光推拉式pH响应探针。
Org Biomol Chem. 2014 Jun 14;12(22):3641-8. doi: 10.1039/c4ob00147h. Epub 2014 Apr 23.
10
Intracellular ion monitoring using a gold-core polymer-shell nanosensor architecture.基于金核-聚合物壳纳米传感器结构的细胞内离子监测。
Nanotechnology. 2010 Feb 5;21(5):055501. doi: 10.1088/0957-4484/21/5/055501. Epub 2009 Dec 21.

引用本文的文献

1
Accelerated proton dissociation in an excited state induces superacidic microenvironments around graphene quantum dots.激发态下加速的质子解离在石墨烯量子点周围诱导出超酸性微环境。
Nat Commun. 2024 Aug 5;15(1):6634. doi: 10.1038/s41467-024-50982-x.
2
A targeted fluorescent nanosensor for ratiometric pH sensing at the cell surface.用于细胞表面比率型 pH 传感的靶向荧光纳米传感器。
Sci Rep. 2024 May 29;14(1):12302. doi: 10.1038/s41598-024-62976-2.
3
Degree of disorder-regulated ion transport through amorphous monolayer carbon.无序调节的离子通过非晶态单层碳的传输程度。
RSC Adv. 2024 May 28;14(24):17032-17040. doi: 10.1039/d4ra01523a. eCollection 2024 May 22.
4
Single-Cell Sensitive Colorimetric pH Detection Based on Microscope Ratiometric Grayscale.基于显微镜比率灰度的单细胞灵敏比色法pH检测
ACS Omega. 2024 May 9;9(20):22240-22247. doi: 10.1021/acsomega.4c01153. eCollection 2024 May 21.
5
Tumor diagnosis using carbon-based quantum dots: Detection based on the hallmarks of cancer.基于碳基量子点的肿瘤诊断：基于癌症特征的检测
Bioact Mater. 2023 Nov 15;33:174-222. doi: 10.1016/j.bioactmat.2023.10.004. eCollection 2024 Mar.
6
Could artificial intelligence revolutionize the development of nanovectors for gene therapy and mRNA vaccines?人工智能能否彻底改变用于基因治疗和mRNA疫苗的纳米载体的研发？
Nano Today. 2022 Dec;47. doi: 10.1016/j.nantod.2022.101665. Epub 2022 Nov 7.
7
Guarding food safety with conventional and up-conversion near-infrared fluorescent sensors.用传统和上转换近红外荧光传感器守护食品安全。
J Adv Res. 2022 Nov;41:129-144. doi: 10.1016/j.jare.2022.01.011. Epub 2022 Jan 30.
8
Carbon dots for cancer nanomedicine: a bright future.用于癌症纳米医学的碳点：光明的未来。
Nanoscale Adv. 2021 Jul 8;3(18):5183-5221. doi: 10.1039/d1na00036e. eCollection 2021 Sep 14.
9
Multicolor Nitrogen-Doped Carbon Quantum Dots for Environment-Dependent Emission Tuning.用于环境依赖发射调谐的多色氮掺杂碳量子点
ACS Omega. 2022 Aug 1;7(31):27742-27754. doi: 10.1021/acsomega.2c03912. eCollection 2022 Aug 9.
10
The Application of Carbon Nanomaterials in Sensing, Imaging, Drug Delivery and Therapy for Gynecologic Cancers: An Overview.碳纳米材料在妇科癌症的传感、成像、药物传递和治疗中的应用：综述。
Molecules. 2022 Jul 13;27(14):4465. doi: 10.3390/molecules27144465.