一种基于碳点的可调比率型 pH 传感器，用于定量测量全细胞的细胞内 pH 值。
A tunable ratiometric pH sensor based on carbon nanodots for the quantitative measurement of the intracellular pH of whole cells.
机构信息
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6432-5. doi: 10.1002/anie.201202533. Epub 2012 May 29.
PMID:22644672
Abstract
The whole picture: Carbon nanodots labeled with two fluorescent dyes have been developed as a tunable ratiometric pH sensor to measure intracellular pH. The nanosensor shows good biocompatibility and cellular dispersibility. Quantitative determinations on intact HeLa cells and pH fluctuations associated with oxidative stress were performed.
摘要
整体情况
已开发出用两种荧光染料标记的碳纳米点作为可调比率比色 pH 传感器，以测量细胞内 pH。该纳米传感器具有良好的生物相容性和细胞分散性。对完整的 HeLa 细胞进行了定量测定，并检测了与氧化应激相关的 pH 波动。
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