通过同位素示踪确定 5-羧基胞嘧啶脱羧的机制和干细胞活性。
Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing.
机构信息
Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universität München, Butenandtstrasse 5-13, 81377 München, Germany.
出版信息
Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6516-20. doi: 10.1002/anie.201202583. Epub 2012 May 29.
PMID:22644704
Abstract
Eraserhead: Stem cells seem to erase epigenetic information by decarboxylation of the newly discovered epigenetic base 5-carboxycytosine (caC; see picture). This reaction is likely to involve a nucleophilic attack of the C5-C6 double bond.
摘要
《橡皮头》：干细胞似乎通过新发现的表观遗传碱基 5-羧基胞嘧啶（caC；见图）的脱羧作用来擦除表观遗传信息。该反应可能涉及 C5-C6 双键的亲核攻击。
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