5,6,8,13-四氢-7H-萘并[2,3-a][3]-苯并氮杂卓-8,13-二酮的合成及抗癌活性。
Synthesis and anticancer activity of 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones.
机构信息
Department of Chemistry, Faculty of Liberal Arts and Science, Kasetsart University, Kampang Saen campus, Nakhon Pathom, Thailand.
出版信息
Arch Pharm Res. 2012 May;35(5):769-77. doi: 10.1007/s12272-012-0502-3. Epub 2012 May 29.
A series of naphthoquinones fused benzazepines, 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones, were synthesized and evaluated for their anticancer activity against four cell lines; human breast carcinoma cell line, human cervix carcinoma cell line, human hepatocellular carcinoma cell line and human keratinocyte cell line. The results showed that 5,6,8,13-tetrahydro-2,3,4,9-tetramethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4g and 5,6,8,13-tetrahydro-2,3,9-trimethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4h have significant cytotoxicity against a hepatocellular carcinoma cell line with IC(50) = 3.5 μg/mL and 3.0 μg/mL, respectively.
一系列萘醌并苯并氮杂卓，5,6,8,13-四氢-7H-萘[2,3-a][3]-苯并氮杂卓-8,13-二酮，被合成并评估了它们对四种细胞系的抗癌活性；人乳腺癌细胞系、人宫颈癌细胞系、人肝癌细胞系和人角质形成细胞系。结果表明，5,6,8,13-四氢-2,3,4,9-四甲氧基-7H-萘[2,3-a][3]苯并氮杂卓-8,13-二酮 4g 和 5,6,8,13-四氢-2,3,9-三甲氧基-7H-萘[2,3-a][3]苯并氮杂卓-8,13-二酮 4h 对肝癌细胞系具有显著的细胞毒性，IC(50)分别为 3.5 μg/mL 和 3.0 μg/mL。
Zotero 插件